How long does it take for Motilium suspension to work against vomiting in children?

Suspension for children Motilium belongs to the group of antiemetics that block dopamine receptors of central action. Stimulates gastrointestinal motility. The preferred dosage form for children is a suspension. The active ingredient is quickly absorbed from the gastrointestinal tract. The maximum concentration of the substance in the blood plasma is reached 1 hour after use.

The product is used to eliminate nausea and vomiting of organic and infectious origin. Used to eliminate regurgitation syndromes after eating in newborns. The product helps get rid of bloating. When using the drug for children, it is important to follow the dosages described in the instructions. Taking in large doses may cause side effects. Before using the product to treat children, you should consult a pediatrician; there are contraindications.

Indications for use

The drug Motilium is used for dyspeptic symptoms associated with the slow movement of food through the gastrointestinal tract. Taking the drug is indicated if the following symptoms are present:

unpleasant sensation in the epigastric region;
flatulence;
reflux of acidic contents from the stomach into the esophagus;
bloating;
damage to the mucous membranes of the esophagus;
pain in the intestines;
belching;
gagging, vomiting.

Indications for taking the composition may also be:

Organic and functional disorders with present nausea or vomiting.
The drug is prescribed to children during infectious diseases to prevent the manifestation of symptoms of intoxication as a result of exposure to harmful microorganisms.
Used for gastrointestinal dysfunction.
The product is used for significant violations of the dietary basis.
Used for the prevention and treatment of regurgitation in infants.

Often the drug is well tolerated, but despite this, you should consult a doctor before taking it. Only a specialist will be able to select the most convenient dosage of the medicinal composition. Consumption of the product is contraindicated in some cases; adverse reactions occur rarely.

Motilium for vomiting in a child: dosage by age

As a result, there is a growing need for drugs that restore the functioning of the gastrointestinal tract.

According to public reviews, Motilium is in the top five among drugs for vomiting and nausea prescribed for children.

At what age should I take it?

The use of Motilium by children under 3 years of age, without a doctor’s prescription, is not allowed.

For infants and children under 5 years of age weighing less than 35 kg, Motilium is prescribed only in the form of a suspension, at the rate of 0.25 mg per 1 kg of weight. For example, a baby weighing 5 kg is recommended to take no more than 1.25 mg of suspension per dose. No side risks have been identified in children, but due to insufficient knowledge of the consequences, the drug is prescribed only for pronounced symptoms.

Children over 5 years old, weighing > 35 kg, and adults are prescribed lozenges and capsules. In some cases (difficulty swallowing, inflammation of the larynx), taking a suspension is allowed. It can be used without a doctor's prescription, strictly according to the instructions.

Directions for use and recommended dosages

The drug Motilium is recommended to be taken 20-30 minutes before meals. This limitation is due to the fact that when consumed after a meal, the absorption of the active substance slows down and effectiveness decreases. The duration of use of the medicinal composition should not exceed 28 days. This is due to the formation of drug addiction, against the background of which a decrease in the effectiveness of the drug occurs.

The recommended dosages of the suspension for children are as follows:

Children over 12 years old with a body weight of more than 35 kg take 10-20 ml of the drug 3-4 times a day. The maximum daily dose is 80 ml of the medicinal composition.
Children under 12 years of age and infants – 0.25-0.5 mg of the product per 1 kg of body weight 3-4 times a day.
The recommended dose can be adjusted by a specialist taking into account the patient's condition. In this case, the maximum volume of medication consumed per day should not exceed 80 ml.
A significant reduction in dosage has been shown for patients with impaired renal function. With long-term use of the composition, it is recommended to monitor the functional activity of organs.
The drug is contraindicated in case of serious liver dysfunction, however, the doctor may prescribe the drug in strictly limited dosages.
Children over 12 years of age and adult patients are recommended to use the drug in tablet form.

Composition and release form

The main active ingredient of the drug Motilium is domperidone. The composition of auxiliary components varies depending on the form of release of the drug:

Suspension is a sweet, jelly-like, whitish liquid, available in 100 ml dark glass bottles, the kit also includes a dispenser syringe. In addition to the main active ingredient, the suspension contains: sodium carmellose, sorbitol, sodium saccharinate, polysorbate 20. The suspension is used for children from the first month of life.
Lozenges with mint flavor - recommended for children over 5 years of age, available in blisters of 10 pieces. Blisters are packed in cardboard boxes of 1-3 pieces. The tablets contain: mint essence, gelatin, mannitol, aspartame, poloxamer 188.
Film-coated tablets are intended for use by children over 12 years of age and adults, available in blisters of 10 pieces. In a cardboard package there are 1 or 3 blisters. Among the excipients in the tablets are: lactose, hypromellose, corn starch, polyvidone, sodium lauryl sulfate.

pharmachologic effect

The drug has an antiemetic effect and stimulates peristalsis. The active component is a dopamine antagonist, but unlike its own analogues, it does not have the ability to penetrate the blood-brain barrier. It is precisely due to this condition that the relative safety of the composition is ensured and the risk of side effects is not high. The main effectiveness of the drug composition is achieved through inhibition of dopamine receptors along with peripheral action. The secretory function of the stomach does not change significantly under the influence of the drug.

Pharmacokinetics

The active component of the drug is quickly absorbed and reaches its maximum concentration in the blood plasma within an hour after consuming the drug. The active component is not collected in the body; the drug is completely processed by the gastrointestinal tract and leaves the patient’s body naturally along with waste products. 31% comes out with urine, and 66% with feces. A small proportion of components are excreted from the body in their original form. The half-life is about 8 hours, longer in patients with impaired liver and kidney function.

Attention! Laboratory studies have proven that the active component has an effect on brain function.

Side effects

Most often, the drug is well tolerated, the described side effects are rare. Among the list of the most common symptoms are:

neurological disorders in the form of prolonged depression, increased excitability;
constant drowsiness and apathy;
recurrent headaches;
disorders of the gastrointestinal tract;
feeling of dry mouth;
deviations in the functioning of the endocrine system;
allergic reactions.

If the described adverse reactions occur, you should consult a doctor and discuss the advisability of prescribing another composition with a similar effect.

Attention! It is prohibited to ignore the manifestation of an allergic reaction and continue taking the composition. Such actions can cause the development of anaphylactic shock.

Neurological disorders most often appear in children under one year of age, since the blood-brain barrier is not developed during this period.

How long does it take for motilium suspension to work against vomiting?

The American Academy of Environmental Medicine officially confirms that the increase in gastrointestinal diseases is associated with the cumulative effect of unnatural food.
But supermarkets leave the buyer no choice. As a result, there is a growing need for drugs that restore the functioning of the gastrointestinal tract.

According to public reviews, Motilium is in the top five among drugs for vomiting and nausea prescribed for children.

The effectiveness of Motilium for vomiting in a child

Among the common disorders in children, motility disorders of the upper gastrointestinal tract, weakened tone and peristalsis of the esophagus and stomach are diagnosed.

The walls of organs stop contracting, food stagnates, rotting begins, irritation of the internal membranes begins, and the acidity of the gastric environment increases. The result is heartburn, nausea, heaviness in the abdomen, gas belching, and vomiting.

To improve the functioning of the gastrointestinal tract and relieve symptoms, it is recommended to take Motilium.

Research by RAS scientists has identified Motilium (the active ingredient domperidone) as the safest drug in terms of contraindications and side effects. Domperidone normalizes muscle tone of the gastrointestinal tract and restores peristalsis. Food is broken down in the stomach and enters the intestines within 2–4 hours.

6 advantages of the medicine:

works on a wide range of symptoms - nausea, vomiting, belching, gas, heaviness in the stomach;
treats chronic diseases;
3 forms of the drug (suspension, capsules, tablet);
rare side effects (35 kg, and an adult is prescribed lozenges, capsules. In some cases (difficulty swallowing, inflammation of the larynx), taking a suspension is allowed. It can be used without a doctor’s prescription, strictly according to the instructions.

Dosage, regimen

There are 3 types of the drug available - lozenges, capsules and children's suspension. In liquid form, the medicine is convenient to dose using a syringe (comes in a box with syrup).

Lozenges (do not swallow) may crack when removed from the blister and may break in the child’s mouth, so you need to take them out carefully. Be sure to shake the suspension before use. The capsule is swallowed (chew, do not break), and washed down with 100 ml of water.

The concentration of the drug in a capsule is 10 mg, in a tablet – 10 mg, blisters are available in 10 and 30 pcs. The volume of the bottle with syrup is 100 ml.

The drug in any form should be drunk 20–30 minutes before meals, since food slows down the breakdown and absorption of the active substance. If necessary, the medicine can be taken before bedtime.

Use for children under 5 years of age

Prescribed only in the form of syrup; tablets are contraindicated. Suspension calculation: 2.5 ml per 10 kg of body weight (0.25 ml per 1 kg). The maximum dosage per day is 30 ml.

For vomiting: 3-4 times a day, with a 4-hour break.
For diarrhea: 3 times a day, with a break of 3-4 hours.

Use in children aged 5–12 years

Prescribed in the form of syrup or tablets. Capsules are not used for patients under 40 kg due to the complexity of dosage.

Calculation: ¼ tablet or 2.5 ml of syrup per 1 kg of body weight. Maximum dose 80 mg.

For vomiting: 4 times a day, every 4 hours.
For diarrhea 3-4 times a day, with an interval of 4-5 hours.

Use for children over 12 years of age

Tablets or capsules are recommended at a rate of 2.5 mg per 1 kg of weight. The maximum daily intake is 80 mg.

For vomiting: 4 times a day;
For diarrhea 4 times a day, simultaneously with taking antidiarrheals.

To eliminate acute manifestations of nausea, vomiting, and when bile is released into the stomach, it is allowed to increase the dosage by 2 times - 2 tablets 3 times a day. If Motilium is ineffective against diarrhea, increasing the dose will not have an effect; it is recommended to reconsider the diagnosis and treatment of the underlying disease.

Duration of admission

For all age groups in the treatment of nausea and vomiting, duration of administration is 5–7 days. If symptoms do not disappear, it is permissible to continue treatment for up to 30 days, after consulting a doctor.

After a month, without changes in the patient’s condition, there is no need to use Motilium due to the ineffectiveness of the prescribed treatment. Re-examination and clarification of the diagnosis are required.

Contraindications

Tablets and capsules are not used for patients weighing less than 35 kg due to the high concentration of the substance. Prescribe with caution to infants in situations where the need for therapy outweighs the risks of side effects. The main factors preventing the use of Motilium are diseases of the gastrointestinal tract, anterior lobes of the pituitary gland and allergic reactions.

The drug is not prescribed in the following cases:

through defects of the gastrointestinal tract;
gastrointestinal bleeding (pancreatic gastrinoma, hyperparathyroidism, Wermer's syndrome, Grönblad's syndrome);
while taking drugs that prolong the electrical systole of the heart (QT interval on ECG) - fluconazole, erythromycin, ketoconazole, telithromycin and analogs;
mechanical obstruction of the intestine (large, small, duodenal) with impaired circulation of the walls;
hypothalamic-pituitary diseases (prolactinoma, hyperprolactinemia);
breast cancer;
individual intolerance to components.

There is not enough information on the use of Motilium during pregnancy and lactation to exclude the drug from prescriptions. There are also no reported data on adverse effects in newborns. But during pregnancy and lactation, the drug is prescribed only in situations where the use of the drug is justified by medical benefits for the patient.

The concentration of domperidone in breast milk is 0.1-0.15% of the dose taken by the mother. The amount of the substance is so small that most likely it has no negative effect. But to avoid risks, it is recommended to stop breastfeeding for the period of therapy.

Side effects

In 98% of studies, the side effects of Motilium on the body were not established. The effectiveness of the drug justifies the risks. Reactions from the nervous system are rarely observed - 1-1.5% of cases. Manifest in the form of mild dizziness, drowsiness, and anxiety syndrome. Women may notice enlargement of the mammary glands and disruption of the menstrual cycle for 3–5 days.

Reactions are rare (in 60 years old taking the drug at a dosage of 30 mg.

If gastrointestinal diseases are not taken into account when prescribing therapy, intestinal spasms, diarrhea, and thirst are possible. Rashes in infants go away on their own after finishing taking Motilium.

Average cost of the drug: in suspension – 500-650 rubles; in tablets and capsules – 150 rubles per blister (10 pieces). Population demand for the drug is high. Motives: relatively low cost, quick effect, minimal risk of side effects and contraindications.

In this article you can read the instructions for use of the drug Motilium . Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Motilium in their practice are presented.

We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Motilium in the presence of existing structural analogues.

Use for the treatment of nausea and vomiting in adults, children, as well as during pregnancy and lactation.

Source: https://morewomen.ru/info/cherez-skolko-dejstvuet-motilium-suspenzija-pri/

Interaction with other drugs

It is not recommended to take Motilium concomitantly with antacid and antisecretory drugs. When they interact, the activity of domperidone is disrupted.

Attention! The active component has a stimulating effect on the tissues of the esophagus and enhances the absorption of other medicinal compounds. That is why the possibility of concomitant use of Motilium with other drugs should be discussed privately.

It is not recommended to use the composition concomitantly with antibiotics.

Analogues of the drug

You can replace Motilium with the following medications:

Motinorm is an Indian drug containing domperidone as an active ingredient. It is produced in a suspension, approved for children over one year of age, and in tablets, which are recommended for patients over 5 years old and weighing more than 20 kg.
Passazhix is a complete analogue of Motilium. This is a domestic medicine, produced in chewable tablets, which can be used in patients over 5 years of age, pregnant women and breastfeeding women.
Perinorm is a substitute for Motilium in the clinical and pharmacological group. This is an antiemetic drug that comes in tablets, ampoules and oral solution. The drug is contraindicated in children under 2 years of age in the first trimester and during breastfeeding.
Cerucal contains metoclopramide as an active ingredient. The drug is available in tablets and injections. Can be used in children over 2 years of age, in the 2nd and 3rd trimester.

Motilium dosage regimen for a child

Children with poisoning should be given Motilium before meals. If the medication is taken after meals, its absorption will slow down.

Patients aged 5-12 years weighing at least 35 kg should be given 1 tablet (10 mg) 3 or 4 times a day.

Children over 12 years of age can be given the medicine 1-2 tablets. The frequency of administration can vary from 3 to 4 times a day.

You should not take more than 8 tablets per day.

Lozenges break easily. Therefore, you need to take the foil by the edges, remove it from the cell and gently press from below to remove the medicine from the package. The drug must be placed on the tongue, after a few seconds it will disintegrate, and Motilium can be swallowed with saliva. Lozenges do not need to be taken with water.

It is recommended to give the medication in liquid form to a child whose weight is less than 35 kg.

The instructions for the Motilium suspension for children state that it should be drunk in the following dosages:

for a child over 12 years old - 10-20 ml;
Motilium for infants and children under 12 years of age is used in a single dose of 0.25-0.5 mg per kg of weight.

The suspension can be drunk 3-4 times a day. To determine the dosage, you need to use the syringe that comes with the kit. It has divisions “0-20 kg”.

Motilium should not be given to a child in case of poisoning without consulting a doctor for more than 28 days in a row.

A small amount of Motilium is excreted in urine, but single dosage adjustment is not required in children with kidney pathologies. But the frequency of taking the medication, depending on the severity of renal failure, should be reduced to 1-2 times a day. Some children with kidney disease may need to reduce the dose of the drug. If the course of treatment is long, the child should be under constant medical supervision.

For mild liver dysfunction, no dosage change is required.

To prevent Motilium from losing its therapeutic effect, the suspension and film-coated tablets should be stored at a temperature of 15-30 degrees. Lozenges should be stored at temperatures up to 25 degrees for 24 months. The suspension has a shelf life of 36 months; Film-coated tablets - 5 years.