Lytic mixture for fever in tablets for a child

Dosage

A lytic mixture for children quickly helps with high fever; the dosage in tablets and ampoules is prepared strictly according to the recipe.
It is impossible to make an effective medicine by eye. It is easy to make a mistake with the dosage, and for a small child, an excess of active ingredients in the composition can end in disaster. Mixing the ingredients is done carefully. When calculating the amount of substance for a formula before the age of one year, the mother should focus on body weight, and after a year on the number of full years.

Injectable medicine for children under one year of age should be prepared based on the following dosage:

• Analgin - 10 mg per kilogram of weight;
• Diphenhydramine - 0.1 ml per kilogram;
• Papaverine - 0.1 ml per kilogram.

The dosage for children over one year of age is as follows:

• 0.1 ml of Analgin, multiplied by the number of full years;
• 0.1 ml Diphenhydramine, multiplied by age;
• 0.1 ml of Papaverine, multiplied by the total number of years.

Understanding how much of each component needs to be taken, the mother will be able to independently prepare a lytic mixture for the child and quickly lower the body temperature.

If the mother does not know how to give an intramuscular injection, she will need to prepare a lytic mixture in tablets. The tablet form of the drug is also effective, although its effect begins a little later.

The following table will show how to determine the dosage for children over 3 years of age:

• 0.25 Analgin tablets;
• 0.3 Diphenhydramine tablets;
• 0.24 tablets of Papaverine.

Mix the finished powder in a spoon with a few drops of water and give it to the child, allowing it to be washed down with clean water. The drug will take effect in 20-30 minutes. The duration of action is the same as that of the composition in ampoules.

Description and preparation

You can prepare the drug in the form of an injection solution and give the child an injection yourself.

If this is not possible (the baby is afraid of injections, you don’t know how to give them, you don’t have a syringe at hand), you should prepare a lytic mixture in tablets.

The main active ingredient is analgin . It reduces fever and relieves pain at the same time.

The composition of the lytic mixture for children in tablets includes Suprastin, which has an antihistamine effect, and No-shpa, which helps relieve vasospasm. Many doctors advise adding a drop of Corvalol to the antipyretic composition.

Indications for use

Lytic mixture is used in children of any age in the following situations:

• temperature rise above 38 °C (with “pale” type fever);
• the appearance of seizures against a background of high temperature;
• lack of effect from other antipyretics;
• pronounced deterioration in the general condition of the child.

The choice of any antipyretic drug is determined by the type of fever. In the medical community, it is customary to distinguish two types of this condition:

• “pink” fever (skin is pink, warm, moist);
• “pale” fever (the skin is pale, dry, cold; cyanosis of the extremities, lips and nails is characteristic).

“Pale” fever is often accompanied by severe chills and a significant deterioration in the child’s general condition. With this pathology, the baby behaves restlessly, is capricious and often cries. Another reaction is possible when the child becomes lethargic and apathetic. Against the background of high temperature, febrile convulsions and toxic brain damage often appear.

The lytic injection is used exclusively for “pale” fever. “Pink” fever is tolerated quite well by children and does not require the use of such potent drugs.

Execution Rules

If a child’s temperature suddenly rises, parents can give themselves an injection. This skill is useful because there is not always time to visit treatment rooms. It is advisable to inject into the muscles of the buttock, since they lack important nerve endings and blood vessels. The procedure will be successful when the medicine is administered quickly and accurately. The child's skin must be folded without stretching it.

At any age, injections are performed when the child is lying stomach down. This is a comfortable position for injection, since the muscles in this position are relaxed. There are a few simple rules to keep in mind:

1. Before and after administering the product, the injection site is treated with alcohol.
2. You need to use a disposable syringe, which must be thrown away after removal.
3. The cycle of injections should be distributed over 2 buttocks.
4. There should be no air bubbles in the syringe. If they occur, they must be sprayed out.

There are several rules for performing such an injection. Each ampoule of the product included in the composition is treated with alcohol. You need to alternately draw a solution of the drug into the syringe: analgin, diphenhydramine, papaverine. In this case, the dosage must be taken into account. The injection is injected into the upper outer quadrant of the buttock 2/3 of the way through the needle. During the procedure, the needle must be held with your little finger so that it does not get stuck in the skin. The needle must be inserted quickly and clearly, the solution should be injected slowly. After this, the needle is quickly removed.

Compatibility with other drugs

The pharmacological compatibility of the lytic mixture is considered in the context of the compatibility of each of its components. Thus, Analgin cannot be used simultaneously with:

• PASKom;
• other analgesics;
• sleeping pills;
• anabolic steroids;
• preparations containing sodium chloride;
• antidiabetic agents;
• anticoagulants.

Diphenhydramine is not compatible with:

• amphotericin B;
• cephalothin sodium;
• hydrocortisone succinate;
• cefmetazole sodium;
• X-ray contrast agents;
• barbiturates;
• solutions of alkalis and strong acids.

Papaverine should not be used simultaneously with:

• tricyclic antidepressants;
• quinidine;
• reserpine;
• procainamide.

Composition of the lytic mixture

The lytic mixture can be prepared as an injection solution or in powder form. In the first case, it is done by mixing solutions from ampoules of different drugs. In the second - from a powder of tablets with different properties.

There are several options for lytic composition. The following mixture of drugs is considered classic:

• non-steroidal anti-inflammatory drug - analgin is used to obtain an antipyretic and analgesic effect;
• antihistamine - diphenhydramine (sometimes suprastin) is used to enhance the effect of the previous drug;
• vasodilator - used to enhance heat transfer and create favorable conditions for eliminating fever; its role is usually performed by papaverine hydrochloride (or its analogue - no-spa).

Once combined in one solution or powder, these products do not create a new substance. After the injection is given or the powder is taken, the medications enter the bloodstream and each begin to act in its own way.

Analogs

If necessary, the components of the lytic mixture can be replaced with similarly active drugs. So, instead of Analgin, Paracetamol or Ibuprofen can be used. Papaverine can be replaced with No-shpa, and Diphenhydramine with Tavegil or Suprastin.

Sources

• https://www.syl.ru/article/208620/new_liticheskaya-smes-ot-temperaturyi-vzroslyim-i-detyam-dozirovka
• https://malutka.pro/preparaty/tabletki/liticheskaya-smes.html
• https://kinders.online/bd/detlekarstva/liticheskaya-smes.html
• https://topotushky.ru/zdorove-malysha/preparaty/liticheskaya-smes-dlya-detej.html
• https://Ukol.expert/zabolevaniya/litichka-ot-temperatury-dlya-detey
• https://FB.ru/article/382351/liticheskiy-ukol-sostav-dozirovka-pravila-primeneniya-plyusyi-i-minusyi-ispolzovaniya
• https://kcdc.ru/aptechka/litichka-ot-temperatury-dlya-detej.html
• https://okrohe.com/deti/meditsinskie-preparaty/liticheskaya-smes.html

Medicines Lytic mixture

Lytic mixture is one of the most popular antipyretic drugs for children and adults today. To bring down a high temperature, you should use a strong remedy, such a remedy is a lytic mixture.

The lytic mixture is also relevant in cases where conventional medications, such as syrups or suppositories, do not help.

The lytic mixture is especially indicated for fever in children, the elderly and groups of people with chronic cardiovascular diseases, and prolonged hyperthermia can cause their exacerbation.

This remedy is also prescribed in cases where there are symptoms of intoxication of the body, with severe vomiting and diarrhea, or with a hangover.

The lytic mixture comes in both tablet and injection form.

Lytic mixture from temperature in tablets

The main advantage of the lytic mixture in tablets is that in the event of an allergic reaction, the patient’s stomach can be washed out. However, the results from taking pills appear later than from injections.

The medicine begins to act only after half an hour. The required dose of the drug should be crushed and diluted with water, and then taken.

Lytic mixture in the form of injections

A faster and more effective remedy is intramuscular injections. This is an excellent way to combat fever, because the effect of the injections becomes noticeable within a quarter of an hour. The injection should be given no more than every 6 hours, and ideally once a day.

Emergency doctors usually intramuscularly inject a lytic mixture of certain parts of diphenhydramine (papaverine) and analgin. This composition brings relief within 15-20 minutes. This happens because analgin in combination with diphenhydramine or papaverine has a very strong antipyretic effect, much greater than the properties of paracetamol or aspirin.

DOSAGE

Dosage for children

Up to 14 years of age is determined by the pediatrician based on the weight and age of the baby. Typically, analgin is taken at 10 mg per 1 kg of baby’s weight, papaverine at 0.1 ml, and diphenhydramine at 0.41 ml for each year of the child’s life.

For adults

Dosage of lytic mixture in tablets

In certain cases, a lytic mixture in tablets may be more appropriate than regular injections. A lytic mixture for fever for children is widely used, the dosage in tablets of which includes the following portions of drugs: ¼ tablets each of analgin, suprastin and no-shpa. The tablets can be crushed and diluted with water, and then given to the child to drink.

The lytic mixture for fever in tablets for adults is also suitable. The proportions of this method of drug administration are simple: 1 tablet of analgin, 1 tablet of suprastin or diphenhydramine and 1 tablet of no-shpa or papaverine. The tablets should be taken with plenty of water.

The effectiveness of the mixture in tablets is much lower. That is, of course, there will be an improvement, but it will not happen immediately.

Preparation

The prepared ampoules are heated to the patient’s temperature (you can simply hold them in your hands) and wipe with alcohol. Having opened the ampoules, the drugs are drawn into the syringe in the following sequence: analgin, diphenhydramine (suprastin), papaverine.

The buttock is conventionally divided into 4 equal parts

The upper outer quadrant is treated with alcohol, the muscles are pinched with your fingers and, holding the syringe at a right angle, the lytic mixture is slowly and very carefully injected

The injection site is again treated with alcohol and for some time, pressing, the tampon is held at the injection site.

Experts do not recommend lowering the temperature below 38.5°C, except in some cases.

Before using such strong remedies as a lytic mixture, you should definitely try to bring down the temperature using gentler methods that will not harm and activate the body to fight the disease. First of all, this includes drinking plenty of fluids. Dehydration is an eternal companion of high temperature. To replenish your electrolyte balance, you should drink more water than usual.

Pills

The lytic remedy for fever does not have to be given as an injection. If the child is conscious and not vomiting, he is allowed to be given pills. They should first be crushed into powder. Take this product with water.

True, improvement in the condition will occur only after 30 minutes. The patient's fever will subside, he will sweat a lot and want to sleep. Be sure to change wet clothes and change your baby into dry pajamas.

Baralgin, Papaverine, Suprastin

The dosage of the drug is prescribed by the doctor based on the severity of the disease and the age of the baby. You can give children only minimal doses of the drug on your own. For example: an adult is given one whole tablet of each remedy for fever at one time.

Lytic mixture for children - composition (from the whole part):

1. Baralgin: ¼.
2. Papaverine: ¼.
3. Suprastin: ¼.

Before using crushed tablets, it is recommended to consult a doctor. Exceeding the dosage is not allowed. After 6 hours, if the fever does not subside, you can take the drug again in the same proportions.

Lytic mixture - dosage for adults

Elevated body temperature accompanies many diseases. However, some people tolerate it quite normally, without experiencing any particular discomfort. Others react very painfully to fever (with the appearance of severe headaches, muscle pain, cramps, delirium, etc.). In such cases, it is advisable to take antipyretic drugs.

But the usual medications for high fever (paracetamol, ibuprofen, etc.) do not always bring the desired effect. Then, as an emergency remedy, you can use a special multicomponent remedy - a lytic mixture, which simultaneously has an antipyretic and analgesic effect, and acts quite quickly (the effect is noted after 15-25 minutes).

How to make a lytic mixture for an adult?

The lytic mixture is a potent mixture of three active components that combine well with each other and are relatively safe for the human body. So, the ingredients of the lytic mixture are:

1. Metamizole sodium (Analgin)
   is a substance from the group of non-steroidal anti-inflammatory drugs that has a powerful antipyretic and pronounced analgesic effect.
2. Papaverine hydrochloride (No-spa)
   is a drug with antispasmodic and hypotensive effects, belonging to the group of opium alkaloids, which, due to vasodilation, increases the heat transfer of the body.
3. Diphenhydramine (Diphenhydramine)
   is a first-generation antihistamine that also has a local anesthetic and sedative effect. This substance enhances the effect of Analgin.

For adult patients, the dosages of no-shpa, analgin and diphenhydramine for a lytic mixture per use are as follows:

• Analgin 50% – 2 ml;
• No-spa 2% – 2 ml;
• Diphenhydramine 1% – 1 ml.

This dosage of the medicine is designed for an adult weighing 60 kg. For every additional 10 kg of weight you should take 1/10 of the above dosage. All components are mixed in one syringe; before opening the ampoules, they should be wiped with alcohol.

The lytic mixture is injected intramuscularly (usually into the outer upper square of the buttock), and the temperature of the solution should correspond to body temperature. The injection should be done in compliance with the rules of asepsis, deep into the muscle, and the medicine should be administered slowly. After the injection, the next administration of the medicinal solution is allowed no earlier than 6 hours later.

Dosage of lytic mixture for adults in tablets

If the use of the lytic mixture in ampoules is not possible, you can use tablets in the dosage for adults:

• 1 tablet of Analgin (or Baralgin);
• 1 tablet No-shpa (Papaverine);
• 1 tablet of Diphenhydramine (Diazolin, Suprastin).

The drugs are taken orally with a sufficient amount of water. It is worth considering that this method of administering a lytic mixture does not give as quick a result as after an injection (no earlier than 30-60 minutes).

Contraindications to the use of the lytic mixture

There are cases when the use of a lytic mixture is prohibited:

1. For abdominal pain of unknown etiology, accompanied by elevated body temperature, seek medical attention. This can be dangerous, for example, in case of appendicitis, because... after taking the lytic mixture, the pain subsides and the symptoms of the disease become hidden.
2. If before this, at least one of the components of the lytic mixture (orally or by injection) was used to relieve fever or pain within 4 hours.
3. In case of individual intolerance to the components of the medicinal mixture.

Dosage and proportions of drug solutions in ampoules for preparing a mixture for injections

The dosage of the lytic mixture is determined by the age and weight of the child.

Analgin 50% solution:

• 0.1-0.2 ml for every 10 kg of weight.

Diphenhydramine, 1% or Suprastin, 2% solution:

• up to 7 years – 0.1 ml for each year of life;
• after 7 years – 1 ml.

Papaverine or No-shpa, 2% solution:

• up to 6 months – not administered;
• from 6 months to 6 years - at the rate of 0.1 ml per year of life;
• over 6 years old – 2 ml.

To avoid an overdose, it is also necessary to observe the total volume of a single and daily dose of the lytic mixture, depending on the weight of the child.

Video on how to properly give an injection in the buttock

How to give an injection for fever

1. First, small doses of these drugs are drawn into one sterile syringe, and then Analgin is added.
2. Before giving the injection, it is necessary to release excess air from the syringe to avoid embolism.
3. For more comfortable administration of the medicine, the syringe can be heated in your hands to body temperature.
4. The injection site is the gluteal muscle. It must be wiped with alcohol to disinfect and prevent abscess.
5. The needle is positioned at an angle of 60 degrees to the surface of the buttock.
6. The injection must be given in the upper right quadrant of the gluteal muscle, since the great vessels do not pass through here and the risk of complications is minimal.
7. The solution is injected very slowly, since the injection itself is quite painful.
8. If the baby is small, you need to turn him over on his tummy on the changing table, or place him on your lap, tightly clasping him with your other hand so that the child does not interfere with the injection.

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Directions for use and dosage

It is strictly forbidden to prepare the lytic mixture “by eye”; to do this, strict proportions must be observed. So, to prepare an injection, 0.1 ml of each substance must be multiplied by the number of full years of the child and mixed together. For example, if a child has already turned 2 full years old, then the dosage of a lytic injection for him will look like this: 0.2 ml of Analgin, 0.2 ml of Diphenhydramine and 0.2 ml of Papaverine mixed together. If we are talking about babies under one year old, then the mixture will consist of 0.1 ml of Diphenhydramine, 0.1 ml of Papaverine and 10 mg of Analgin per 1 kg of body weight (1 ml contains 500 mg of the substance). To prepare a lytic mixture for children over 12 years of age and adults, the dosage is as follows: 1 ampoule of each component is mixed together in equal proportions.

The finished injection is administered intramuscularly, usually into the upper outer square of the buttock. Taking this mixture orally is also acceptable, but is not recommended due to the longer onset of the effect (no less than 30 minutes) and the negative impact of analgin on the mucous membrane of the stomach and intestines.

As for the preparation of a lytic mixture for children in tablet form, here, regardless of age (and this form of medication is allowed only from 3 years), the following dosage is used: 1/4 tablet of Analgin, 1/3 tablet of Diphenhydramine and 1/ 4 tablets of Papaverine. In this case, the required number of tablets must be crushed into powder, mixed, and after ingestion, give the child a sufficient amount of boiled water.

When using this drug in tablet form, the effect also occurs with a “delay” - after about 30 minutes, however, the advantage of this form is the ability to perform gastric lavage in case of an overdose or individual intolerance.

It is prohibited to reuse the lytic mixture or preparations containing its components within 6 hours after the initial use.

Injections

Injections that include two or three medications at once are given to children over three years of age no more than once every 6 hours, and for children under three years of age - once every 24 hours. They are used if antipyretic syrups and suppositories do not help the baby. Intramuscular injection. Improvement occurs after 10 minutes.

Analgin with Diphenhydramine

Children under 1.5 years old are often given injections of two medications when they have a fever - Analgin and Diphenhydramine. Together, these drugs have a rapid fever-reducing effect.

Composition of infant formula (up to 1.5 years):

1. Analgin: 10 mg multiplied by weight in kg.
2. Diphenhydramine: 0.1 ml.

It’s easy to give an injection: you need to take a 2 ml or 5 ml syringe and draw the required amount of medicine from the ampoules. The injection is given in the upper outer quadrant of the buttock. The needle enters the muscle perpendicularly. The medicine is administered smoothly and very slowly.

Troychatka – Analgin, Diphenhydramine, Papaverine

The triad is prepared from three medications. For babies up to 12 months and children after one year, the composition of this mixture is slightly different. With age, the amount of active substances increases.

Troychatka for children up to 12 months:

1. Analgin (50%): 10 mg multiplied by the baby's weight.
2. Diphenhydramine (2%): 0.1 ml.
3. Papaverine (2%): 0.1 ml.

How many ml of each drug is taken for formula for children after 1 year:

1. Analgin (50% solution of Metamizole sodium): 0.1 ml multiplied by age.
2. Diphenhydramine (2%): 0.1 ml multiplied by age.
3. Papaverine (2%): 0.1 ml multiplied by age.

Important! The medicinal mixture should not be prepared by eye. You need to keep the proportions exactly. For children under one year of age, the dose is calculated based on body weight, and after one year - based on the number of full years lived.

Analgin, Paracetamol, Suprastin (Tavegil, Fenistil)

Troychatka is also prepared with Suprastin or Tavegil. These drugs have an antiallergic effect. They are used to reduce the level of toxicity during the inflammatory process.

Recipe for preparing the mixture:

1. Analgin: 0.1 ml multiply the number of full years.
2. Paracetamol: 0.1 ml multiplied by the number of completed years.
3. Suprastin: 0.1 ml multiply the number of full years.

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Before injecting the ampoule, you need to hold it in your hand for some time to warm it up. The administered medicine must be at body temperature. The syringe is used only for disposable use. Does not apply again. All components of the mixture are mixed in one syringe.

What is a lytic mixture and its composition

When your child shows signs of fever, you need to act decisively. If no other means help, then you will have to use a lytic mixture

, which will help reduce high fever and eliminate the inflammatory process. But this remedy should be resorted to only as a last resort and as a last resort. The fact is that in the future, for colds, treatment with usual medications will not have the desired effect, and the effect of antipyretic drugs will be weak.

This mixture contains three components:

• Analgin (is the main antipyretic and analgesic component);
• Diphenhydramine (enhances the effect of analgin and also has an antihistamine effect);
• Papaverine (increases heat transfer from the body and lowers temperature due to the fact that spasms are reduced and blood vessels dilate, enhances the effect of analgin).

Diphenhydramine can be replaced with Suprastin, Fenistil or Tavegil. Papaverine can be replaced by No-shpa.

According to doctors, the temperature needs to be brought down only when it exceeds 38.5°C. Until then, the body itself must fight the disease. An exception may be the following symptoms, in which the body temperature is about 37.5°C:

This medicine effectively fights fever when other remedies have failed. If the symptoms include fever and severe chills, then a lytic mixture is often used. But the drug can also cause complications, so you should not use it uncontrollably. You must first consult your doctor. With frequent use of the mixture, the child is likely to develop immunity to other antipyretic drugs. The injection begins to act after 30 minutes, the temperature stops rising, and the body is able to fight the disease.

It is also necessary to remember that the composition and dosage of the medicine is for adults and children. The medicine also eliminates the symptoms of intoxication of the body during a hangover.

Contraindications

In some cases, the drug cannot be used even at very high temperatures:

• the child is less than 6 months old;
• fever is accompanied by abdominal pain - this can be dangerous in acute appendicitis;
• over the last 4 hours the patient has already taken the drugs included in the product (Analgin, No-shpu, Suprastin);
• the baby is allergic to one of the medicinal components.

Before the injection, it is easy to check for allergic reactions - just drop a drop of medicine under the child’s lower eyelid. If you prepare the mixture in tablets, you will have to rely on what you already know about your baby’s allergic reactions.

What can replace the lytic composition?

An excellent alternative to injections would be a complex of Suprastin, Papaverine and Baralgin tablets. Instead of Papaverine, you can use No-shpa, and instead of Suprastin - Diazolin. In the mixture for injections, Diphenhydramine can be replaced with Suprastin or Tavegil, which have a pronounced antiseptic effect.

It is not always possible to choose an effective drug to treat influenza. In many cases, elevated body temperature is accompanied by dehydration and intoxication of the body, and can manifest itself as severe headaches and muscle pain, and the appearance of seizures. When aspirin and non-steroidal anti-inflammatory drugs (indomethacin, ibuprofen and naklofen) are powerless, it is recommended to use such a mixture.

If the temperature regime is violated, parents give the baby antipyretic drugs, which are not always highly effective. There is another reliable remedy, but the recipe for the lytic mixture is not known to everyone. The medicinal composition removes signs of the inflammatory process and normalizes body temperature.

Reviews

Varvara:

We were injected with lytichka several times, but this was done exclusively by the ambulance staff, which I called when I was powerless in the face of high fever. I know that it is undesirable to do this, but I think that it is definitely safer for the child than a temperature of 40. This remedy has helped us every time. In such cases, I am glad to find any way to alleviate the suffering of my baby.

Lydia:

I give my son a similar mixture at high temperatures: Nurofen, No-shpa and Suprastin. It helps every time. But I try not to abuse it.

Elena:

Once upon a time, a doctor gave us such a recipe in an ambulance. Since then, I never call the emergency room when I have a fever like this with cold arms and legs. And I mix a quarter of the tablets of Analgin, No-shpa and Suprastin - and the temperature quickly drops on its own. Of course, you shouldn’t expect that after 39.5 it will immediately drop to 36.0. If in this case it drops to at least 38.0, that’s already good.

Oksana:

I give a similar remedy to my daughter when she has a high temperature: 1/4 tablet of Suprastin and 1/3 tablet of No-shpa. Always a good help.

Catherine:

Now there are so many different antipyretic drugs! I would never poison my child with Analgin. What about “emergency”? The main thing for them is to give an injection that would bring down the temperature quickly (but this does not mean that it is safe), so as not to “cook” you for 2 hours.

Indications for use

Lytic mixture is used in children of any age in the following situations:

• temperature rise above 38 °C (with “pale” type fever);
• the appearance of seizures against a background of high temperature;
• lack of effect from other antipyretics;
• pronounced deterioration in the general condition of the child.

The choice of any antipyretic drug is determined by the type of fever. In the medical community, it is customary to distinguish two types of this condition:

• “pink” fever (skin is pink, warm, moist);
• “pale” fever (the skin is pale, dry, cold; cyanosis of the extremities, lips and nails is characteristic).

“Pale” fever is often accompanied by severe chills and a significant deterioration in the child’s general condition. With this pathology, the baby behaves restlessly, is capricious and often cries. Another reaction is possible when the child becomes lethargic and apathetic. Against the background of high temperature, febrile convulsions and toxic brain damage often appear.

The lytic injection is used exclusively for “pale” fever. “Pink” fever is tolerated quite well by children and does not require the use of such potent drugs.